translation: GoogleTranslate/doxa-louise
Origins of the coronavirus: “A piece of the puzzle is still missing”
RENNES | How did the new coronavirus appear and then migrate the bats to humans? "A piece of the puzzle is still missing," says researcher Meriadeg Le Gouil, who is coordinating a research project in France on the origins of the pandemic.
"No one can say that they understood the emergence of this virus", underlines to AFP the virologist and ecologist at the University of Caen (west), member of the Research group on microbial adaptation (Gram) .
“In this coronavirus, we find traces of several viruses that we know in the wild. Except that we don't know recent parents, we only know cousins, "explains the 39-year-old researcher, who excludes a" synthetic origin "of the virus (for example in a Chinese laboratory).
The debate on the origins of the virus has diplomatic repercussions, the United States accusing a Chinese laboratory, in Wuhan, of being at the origin of the coronavirus which Beijing denies.
But according to the vast majority of researchers, the coronavirus has been transmitted to humans by an animal. A Wuhan market has been pointed to by Chinese scientists for allegedly selling live wild animals.
With genetic analysis, scientists were able to compare SARS-CoV-2 with a virus collected in 2013 from a bat in Yunnan (southern China), with which it is similar to 96% on average.
If a direct transmission from the bat to humans is "possible", it is however not the most probable hypothesis, according to this specialist in coronaviruses, because close, numerous and frequent contacts are necessary for 'a virus to make a species jump. "Unless we discover an absolutely gigantic traffic in bats over the last three years", he adds.
"The second option would be the breeding of another wild animal" which would have served as an intermediate host between the bat and humans, explains Mr. Le Gouil. "It is missing a piece of the puzzle", which is perhaps not the pangolin, frequently mentioned, but the civet-cat, he advances.
This small mammal, the Breton researcher had already met him within the framework of the emergence of another epidemic due to a coronavirus, the SARS of 2002 (or SARS-CoV), subject of his thesis six years later.
The Wild cat, an ideal suspect?
"Civet is a bit like our venison, a dish eaten on special occasions", he describes. "It is a carnivore close to the dog and the cat (...) which frequents caves, eats a bat from time to time."
“Civet farming had increased 50-fold in the five years before SARS emerged. The civet caught in the wild was brought back to civet farms, which favored the birth of a variant of coronavirus, present only in civets raised by humans, "added the researcher.
Today, Chinese scientists "publish 10 articles a day and nothing on farms in the region. It's just very surprising for someone who is aware of the emergence of coronaviruses, ”says Meriadeg Le Gouil. "I would give anything to go and sample in China all the types of breeding that were going on in the region three or four months ago."
The Discover research project that he coordinates precisely aims to follow the trail of SARS-CoV-2, by studying the prevalence, diversity and evolution over time of coronaviruses in different species in the north of Laos and Thailand. .
“The goal is not necessarily to find the missing piece that may have disappeared since. But we will have clues and a bundle of arguments to better understand what happened, ”explains the researcher. "We will at least have a very good overview of what happened around and just before."
It is also a question of "targeting risky practices" for the emergence of viruses, such as the breeding of civets. "There is obviously a link between the overflow of humans into wildlife, the way in which we interact with nature, and the emergence of pathogens," he says. "We can clearly see the links between ecosystem health and human health."
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